178 Activation of epigenetic Sirt1 synthesis by a fucus vesiculosus extract

Epigenetic marks such as the acetylation of histones change substantially with aging or UV exposure. Increase histone could be related to decrease SIRT-1 deacetylase enzyme and its NAD+ co-factor produced by mitochondria at same time ATP. appears a highly relevant epigenetic marker cell activity while ATP mitochondrial materialize measurable consequences. The purpose this study was evaluate capacity an algae extract reactivate synthesis, production, improve vitality thus limiting senescence signs. Experimentation were performed on normal human dermal fibroblasts (NHDF). Capillary electrophoresis-based protein analysis system (Sally Sue) used quantify protein. production evaluated luminescent assay spectrophotometry. NHDF treated for 24h 0.002% resveratrol, known inducer SIRT-1, 1% SVF 0.02% Fucus vesiculosus enriched in fucoidans. Resveratrol significantly stimulated 35% synthesis versus untreated control. Interestingly, induced better extent (+ 42%). Moreover, respectively 138% 258% is regulator protector longevity through deacetylation associated energy activity. Our specific has particularly showed, ability stimulate efficiently but without stability issue formulation. Altogether, these results demonstrated that may act process increase into dermis, signs skin roughness dullness.